![]() ![]() A comparative lack of data for men is an important confounding factor. This may be because migraine is more common in women or maybe due to changes in endogenous and exogenous hormone levels. There is a general agreement in the literature that women with migraine are at a higher risk of vascular disease as compared to men. Data about hemorrhagic stroke, myocardial infarction, and cardiovascular mortality is less clear. The association is strongest between migraine with aura (MA) (a third of migraineurs may have an aura associated with headache) and ischemic stroke. A growing body of evidence in literature identifies migraine as a risk factor for stroke and CVD. ![]() As per the “Global Burden of Diseases Study” migraine is amongst the leading causes of disability worldwide in individuals less than 50 years of age. Migraine is a common disabling neurologic illness, and affects approximately 20% of the world's population, with the highest prevalence in women of reproductive age group. How to cite this URL: Gupta A, Srivastava M V. How to cite this article: Gupta A, Srivastava M V. Ergot alkaloids/triptans should be avoided in presence of CVD. The presence of aura, smoking, CVD, age, and estrogen content are important considerations before the use of hormonal agents in women with migraine. The relationship persists after adjustment of traditional vascular risk factors. The evidence is robust for migraine with aura and ischemic stroke and variable for other cardiovascular diseases (CVDs). Key Messages: Migraine is being increasingly associated with vascular disease. Keywords: Aura, migraine, stroke, vascular The association with hemorrhagic stroke is more variable.Ĭonclusion: Although the absolute effect of migraine on 'vascular risks' is small, good practice parameters dwell on treating and reducing existing cardiovascular risk factors through lifestyle modification, encouraging smoking cessation, and advocating the wise use of agents like ergot alkaloids and oral contraceptives, after a risk-benefit analysis. There is some evidence linking an adverse vascular risk factor profile to incident myocardial infarction in people with migraine. Although literature reports a higher prevalence of obesity, dyslipidemia, and family history of cardiovascular diseases in migraineurs, the 'migraine-vascular' connection persists in models where the traditional vascular risk factors are adjusted, implicating a migraine-specific pathophysiology at work. Results: The association between migraine and vascular diseases is strong and consistent for ischemic stroke and migraine with aura especially in young women, with oral contraceptive use and smoking. We also searched the reference lists of articles obtained and included some insightful reviews on 'Migraine and Vascular Risk'. We studied articles mostly in English for the past 10 years, without excluding older articles that were relevant to this review. Methods and Materials: We searched PUBMED database using the MeSH terms “Stroke”, “Coronary Artery Disease”, “Myocardial Ischemia”, “Atrial Fibrillation”, “White Matter” and “Dementia, Vascular”, in combination with “Migraine Disorders”, “Migraine with Aura” and “Migraine without Aura” and reviewed the relevant studies. Objective: The aim of this study was to provide an update on the association of migraine with some common vascular diseases in persons suffering from the disease and discuss the clinical implications. There is growing evidence that migraine is associated with cardiovascular diseases and stroke. Background: Migraine is a common neurological disorder with significant morbidity and disability.
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